扫 描 看 全 文
1.中南大学湘雅三医院皮肤科, 长沙 410013
2.西北大学费因伯格医学院皮肤科, 伊利诺伊州 芝加哥 60611-3008, 美国
WANG Xiaoqi, Email: xiaoqiwang26@gmail.com
王晓琦. 医用臭氧在皮肤疾病中的创新性应用[J]. Journal of Central South University (Medical Science), 2018,43(2):114-123.
Xiaoqi WANG. Emerging roles of ozone in skin diseases[J]. 中南大学学报(医学版), 2018,43(2):114-123.
王晓琦. 医用臭氧在皮肤疾病中的创新性应用[J]. Journal of Central South University (Medical Science), 2018,43(2):114-123. DOI: 10.11817/j.issn.1672-7347.2018.02.002.
Xiaoqi WANG. Emerging roles of ozone in skin diseases[J]. 中南大学学报(医学版), 2018,43(2):114-123. DOI: 10.11817/j.issn.1672-7347.2018.02.002.
自19世纪中期人们发现了臭氧, 臭氧的多种治疗作用已被广泛接受并常用于杀菌消毒. 一个多世纪的研究表明臭氧在实施多种治疗作用的同时, 其毒副作用完全可控. 近期的研究更证明了臭氧在感染性皮肤病、皮炎湿疹类皮肤病及皮肤慢性溃疡等疾病中的治疗作用. 本课题组将臭氧广泛应用于治疗多种皮肤疾病, 并致力于研究医用臭氧的疗效和安全性. 此外本文也讨论了臭氧治疗的可能作用机制和未来的研究方向.
Ozone was discovered in the mid-nineteenth century and is proven to have many therapeutic effects, including its common application as a disinfectant to kill microorganisms in various conditions. Ozone therapies have been utilized for various purposes ever since it was discovered. Extensive studies over a century have verified its therapeutic effects, consistency, and safety with minimal and preventable side effects in medical care. Emerging evidence revealed that ozone also plays important roles in the management and prevention of various skin disorders including infectious skin diseases, skin related allergic diseases, erythema scaly diseases, wound healing and ulcer recovery. Herein, the author now summarizes the recent clinical applications of ozone therapy in dermatology and provide commentary on what we have learned in our practice. Our focuses are the efficacy and safety of ozone therapies as well as the application prospects of ozone on various skin disorders. In addition, the author discusses the potential mechanisms involved in ozone therapy and the efforts we should make for.
臭氧皮肤病临床应用治疗皮肤病学
ozoneskin disordersclinical applicationtherapydermatology
Elvis AM, Ekta JS. Ozone therapy: A clinical review[J].J Nat Sci Biol Med, 2011, 2(1): 66-70.
Ozturk B, Kurtoglu T, Durmaz S, et al. The effects of ozone on bacterial growth and thiol-disulphide homeostasis in vascular graft infection caused by MRSA in rats[J].Acta Cir Bras, 2017, 32(3): 219-228.
Delgado-Roche L, Riera-Romo M, Mesta F, et al. Medical ozone promotes Nrf2 phosphorylation reducing oxidative stress and pro-inflammatory cytokines in multiple sclerosis patients[J].Eur J Pharmacol, 2017, 811: 148-154.
Mirowsky JE, Dailey LA, Devlin RB. Differential expression of pro-inflammatory and oxidative stress mediators induced by nitrogen dioxide and ozone in primary human bronchial epithelial cells[J].Inhal Toxicol, 2016, 28(8): 374-382.
Borges GA, Elias ST, Da SS, et al. In vitro evaluation of wound healing and antimicrobial potential of ozone therapy[J].J Craniomaxillofac Surg, 2017, 45(3): 364-370.
Bocci V, Zanardia I, Valacchi G, et al. Validity of oxygen-ozone therapy as integrated medication form in chronic inflammatory diseases[J].Cardiovasc Hematol Disord Drug Targets, 2015, 15(2): 127-138.
Liu J, Zhang P, Tian J, et al. Ozone therapy for treating foot ulcers in people with diabetes[J].Cochrane Database Syst Rev, 2015(10): D8474.
Avci S, Buyukcam F, Demir OF, et al. Anton syndrome during oxygen-ozone therapy[J].Am J Emerg Med, 2015, 33(6): 851-856.
Abeck D, Plotz S. Colloidal silver and ozonized olive oil for atopic dermatitis?[J].Med Monatsschr Pharm, 2008, 31(7): 265-266.
张英博, 向亚平, 黄进华, 等. 联合臭氧水治疗特应性皮炎患者的疗效及白细胞介素4、神经生长因子检测[J].中华皮肤科杂志, 2016, 49(10): 736-738.
ZHANG Yingbo, XIANG Yaping, HUANG Jinhua, et al. Combined ozone hydrotherapy for atopic dermatitis: evaluation of efficacy and detection of interleukin-4 andnerve growth factor levels in peripheral blood from patients before and after treatment[J].Chinese Journal of Dermatology, 2016, 49(10): 736-738.
Hanaoka T, Kamimura N, Yokota T, et al. Molecular hydrogen protects chondrocytes from oxidative stress and indirectly alters gene expressions through reducing peroxynitrite derived from nitric oxide[J].Med Gas Res, 2011, 1(1): 18.
Zu K, Liu X, Shi L, et al. Corrigendum to “Concentration-response of short-term ozone exposure and hospital admissions for asthma in Texas” Environmental International 104 (2017): 139-145[J].Environ Int, 2017, 109: 193-194.
Martinez-Lazcano JC, Gonzalez-Guevara E, Del CRM, et al. The effects of ozone exposure and associated injury mechanisms on the central nervous system[J].Rev Neurosci, 2013, 24(3): 337-352.
Hernandez RF, Calunga FJ, Turrent FJ, et al. Ozone therapy effects on biomarkers and lung function in asthma[J].Arch Med Res, 2005, 36(5): 549-554.
Sagai M, Bocci V. Mechanisms of action involved in ozone therapy: Is healing induced via a mild oxidative stress?[J].Med Gas Res, 2011, 1: 29.
Anitua E, Zalduendo MM, Troya M, et al. Ozone dosing alters the biological potential and therapeutic outcomes of plasma rich in growth factors[J].J Periodontal Res, 2015, 50(2): 240-247.
Braslavsky SE, Rubin MB. The history of ozone. Part VIII. Photochemical formation of ozone[J].Photochem Photobiol Sci, 2011, 10(10): 1515-1520.
Bocci V, Di Paolo N. Oxygen-ozone therapy in medicine: an update[J].Blood Purif, 2009, 28(4): 373-376.
Stubinger S, Sader R, Filippi A. The use of ozone in dentistry and maxillofacial surgery: a review[J].Quintessence Int, 2006, 37(5): 353-359.
Garber GE, Cameron DW, Hawley-Foss N, et al. The use of ozone-treated blood in the therapy of HIV infection and immune disease: a pilot study of safety and efficacy[J].AIDS, 1991, 5(8): 981-984.
Bocci V, Venturi G, Catucci M, et al. Lack of efficacy of ozone therapy in HIV infection[J].Clin Microbiol Infect, 1998, 4(11): 667-669.
Chen H, Yu B, Lu C, et al. The effect of intra-articular injection of different concentrations of ozone on the level of TNF-alpha, TNF-R1, and TNF-R2 in rats with rheumatoid arthritis[J].Rheumatol Int, 2013, 33(5): 1223-1227.
Lintas G, Molinari F, Simonetti V, et al. Time and time-frequency analysis of near-infrared signals for the assessment of ozone autohemotherapy long-term effects in multiple sclerosis[J].Conf Proc IEEE Eng Med Biol Soc, 2013, 2013: 6171-6174.
Borrelli E, Diadori A, Zalaffi A, et al. Effects of major ozonated autohemotherapy in the treatment of dry age related macular degeneration: a randomized controlled clinical study[J].Int J Ophthalmol, 2012, 5(6): 708-713.
Di Paolo N, Gaggiotti E, Galli F. Extracorporeal blood oxygenation and ozonation: clinical and biological implications of ozone therapy[J].Redox Rep, 2005, 10(3): 121-130.
Singh BP, Kumar A, Singh D, et al. An assessment of ozone levels, UV radiation and their occupational health hazard estimation during photocopying operation[J].J Hazard Mater, 2014, 275: 55-62.
Bocci V, Borrelli E, Travagli V, et al. The ozone paradox: ozone is a strong oxidant as well as a medical drug[J].Med Res Rev, 2009, 29(4): 646-682.
Song M, Zeng Q, Xiang Y, et al. The antibacterial effect of topical ozone on the treatment of MRSA skin infection[J].Mol Med Rep, 2018, 17(2): 2449-2455.
Maritza F, Díaz G, Goitybell Martínez T, et al. Chemical analysis of ozonized theobroma fat[J].J Amer Oil Chem Soc, 2006, 83(11): 4.
Sanhueza PA, Reed GD, Davis WT, et al. An environmental decision-making tool for evaluating ground-level ozone-related health effects[J].J Air Waste Manag Assoc, 2003, 53(12): 1448-1459.
Sweet F, Kao MS, Lee SC, et al. Ozone selectively inhibits growth of human cancer cells[J].Science, 1980, 209(4459): 931-933.
Travagli V, Zanardi I, Valacchi G, et al. Ozone and ozonated oils in skin diseases: a review[J].Mediators Inflamm, 2010, 2010: 610418.
Sega A, Zanardi I, Chiasserini L, et al. Properties of sesame oil by detailed 1H and 13C NMR assignments before and after ozonation and their correlation with iodine value, peroxide value, and viscosity measurements[J].Chem Phys Lipids, 2010, 163(2): 148-156.
Valacchi G, Lim Y, Belmonte G, et al. Ozonated sesame oil enhances cutaneous wound healing in SKH1 mice[J].Wound Repair Regen, 2011, 19(1): 107-115.
Menendez S, Falcon L, Maqueira Y. Therapeutic efficacy of topical OLEOZON(R) in patients suffering from onychomycosis[J].Mycoses, 2011, 54(5): e272-e277.
Guerrer LV, Cunha KC, Nogueira MC, et al. “In vitro” antifungal activity of ozonized sunflower oil on yeasts from onychomycosis[J].Braz J Microbiol, 2012, 43(4): 1315-1318.
Pai SA, Gagangras SA, Kulkarni SS, et al. Potential of ozonated sesame oil to augment wound healing in rats[J].Indian J Pharm Sci, 2014, 76(1): 87-92.
Molinari F, Simonetti V, Franzini M, et al. Ozone autohemotherapy induces long-term cerebral metabolic changes in multiple sclerosis patients[J].Int J Immunopathol Pharmacol, 2014, 27(3): 379-389.
Carli AB, Incedayi M. Oxygen-ozone autohemotherapy in sacroiliitis[J].Acta Reumatol Port, 2017, 42(4):334-335.
Gupta G, Mansi B. Ozone therapy in periodontics[J].J Med Life, 2012, 5(1): 59-67.
Bassi P, Sbrascini S, Mattassi R, et al. Ozone in the treatment of herpes zoster[J].Riv Neurobiol, 1982, 28(3/4): 328-333.
Wu D, Tan W, Zhang Q, et al. Effects of ozone exposure mediated by BEAS-2B cells on T cells activation: a possible link between environment and asthma[J].Asian Pac J Allergy Immunol, 2014, 32(1): 25-33.
Williams AS, Mathews JA, Kasahara DI, et al. Innate and ozone-induced airway hyperresponsiveness in obese mice: role of TNF-alpha[J].Am J Physiol Lung Cell Mol Physiol, 2015, 308(11): L1168-L1177.
Travagli V, Zanardi I, Silvietti A, et al. A physicochemical investigation on the effects of ozone on blood[J].Int J Biol Macromol, 2007, 41(5): 504-511.
Polydorou O, Halili A, Wittmer A, et al. The antibacterial effect of gas ozone after 2 months of in vitro evaluation[J].Clin Oral Investig, 2012, 16(2): 545-550.
Thanomsub B, Anupunpisit V, Chanphetch S, et al. Effects of ozone treatment on cell growth and ultrastructural changes in bacteria[J].J Gen Appl Microbiol, 2002, 48(4): 193-199.
Brodowska AJ, Nowak A, Kondratiuk-Janyska A, et al. Modelling the ozone-based treatments for inactivation of microorganisms[J].Int J Environ Res Public Health, 2017, 14(10): pii: E1196.
Gupta AK, Brintnell WC. Sanitization of contaminated footwear from onychomycosis patients using ozone gas: a novel adjunct therapy for treating onychomycosis and tinea pedis?[J].J Cutan Med Surg, 2013, 17(4): 243-249.
Bocci V, Zanardi I, Travagli V. Ozonation of human HIV-infected plasmas for producing a global vaccine: How HIV-patients may help fight the HIV pandemia[J].Virulence, 2010, 1(3): 215-217.
Di Filippo C, Trotta MC, Maisto R, et al. Daily oxygen/O3 treatment reduces muscular fatigue and improves cardiac performance in rats subjected to prolonged high intensity physical exercise[J].Oxid Med Cell Longev, 2015, 2015: 190640.
Nathan C. Immunology. Catalytic antibody bridges innate and adaptive immunity[J].Science, 2002, 298(5601): 2143-2144.
Schulz S, Ninke S, Watzer B, et al. Ozone induces synthesis of systemic prostacyclin by cyclooxygenase-2 dependent mechanism in vivo[J].Biochem Pharmacol, 2012, 83(4): 506-513.
Bocci VA. Scientific and medical aspects of ozone therapy. State of the art[J].Arch Med Res, 2006, 37(4): 425-435.
Bocci V. The case for oxygen-ozonetherapy[J].Br J Biomed Sci, 2007, 64(1): 44-49.
Coppola L, Giunta R, Verrazzo G, et al. Influence of ozone on haemoglobin oxygen affinity in type-2 diabetic patients with peripheral vascular disease: in vitro studies[J].Diabete Metab, 1995, 21(4): 252-255.
Xiao W, Tang H, Wu M, et al. Ozone oil promotes wound healing by increasing the migration of fibroblasts via PI3K/Akt/mTOR signaling pathway[J].Biosci Rep, 2017, 37(6): pii: BSR20170658.
Valacchi G, Bocci V. Studies on the biological effects of ozone: 10. Release of factors from ozonated human platelets[J].Mediators Inflamm, 1999, 8(4/5): 205-209.
Bocci V, Zanardi I, Travagli V. Ozone: a new therapeutic agent in vascular diseases[J].Am J Cardiovasc Drugs, 2011, 11(2): 73-82.
Luo WJ, Yang F, Yang F, et al. Intervertebral foramen injection of ozone relieves mechanical allodynia and enhances analgesic effect of gabapentin in animal model of neuropathic pain[J].Pain Physician, 2017, 20(5): E673-E685.
Alberto PO. Ozone the one and only drug[J].Acta Neurochir Suppl, 2011, 108: 143-146.
Bocci V. Ozone as Janus: this controversial gas can be either toxic or medically useful[J].Mediators Inflamm, 2004, 13(1): 3-11.
Jordan L, Beaver K, Foy S. Ozone treatment for radiotherapy skin reactions: is there an evidence base for practice?[J].Eur J Oncol Nurs, 2002, 6(4): 220-227.
Bocci V, Zanardi I, Borrelli E, et al. Reliable and effective oxygen-ozone therapy at a crossroads with ozonated saline infusion and ozone rectal insufflation[J].J Pharm Pharmacol, 2012, 64(4): 482-489.
Kucuksezer UC, Zekiroglu E, Kasapoglu P, et al. A stimulatory role of ozone exposure on human natural killer cells[J].Immunol Invest, 2014, 43(1): 1-12.
Peden DB. The role of oxidative stress and innate immunity in O3 and endotoxin-induced human allergic airway disease[J].Immunol Rev, 2011, 242(1): 91-105.
Bicer S, Sayar I, Gursul C, et al. Use of ozone to treat ileostomy dermatitis in an experimental rat model[J].Med Sci Monit, 2016, 22: 757-765.
Gulmen S, Kurtoglu T, Meteoglu I, et al. Ozone therapy as an adjunct to vancomycin enhances bacterial elimination in methicillin resistantStaphylococcus aureus mediastinitis[J].J Surg Res, 2013, 185(1): 64-69.
Moureu S, Violleau F, Ali HD, et al. Ozonation of sunflower oils: impact of experimental conditions on the composition and the antibacterial activity of ozonized oils[J].Chem Phys Lipids, 2015, 186: 79-85.
Guinesi AS, Andolfatto C, Bonetti FI, et al. Ozonized oils: a qualitative and quantitative analysis[J].Braz Dent J, 2011, 22(1): 37-40.
Wainstein J, Feldbrin Z, Boaz M, et al. Efficacy of ozone-oxygen therapy for the treatment of diabetic foot ulcers[J].Diabetes Technol Ther, 2011, 13(12): 1255-1260.
Carpendale MT, Freeberg JK. Ozone inactivates HIV at noncytotoxic concentrations[J].Antiviral Res, 1991, 16(3): 281-292.
Xie TY, Yan W, Lou J, et al. Effect of ozone on vascular endothelial growth factor (VEGF) and related inflammatory cytokines in rats with diabetic retinopathy[J].Genet Mol Res, 2016, 15(2): 1-11.
Johansson E, Claesson R, van Dijken JW. Antibacterial effect of ozone on cariogenic bacterial species[J].J Dent, 2009, 37(6): 449-453.
Tusat M, Mentese A, Demir S, et al. Medical ozone therapy reduces oxidative stress and testicular damage in an experimental model of testicular torsion in rats[J].Int Braz J Urol, 2017, 43(6): 1160-1166.
Zanardi I, Borrelli E, Valacchi G, et al. Ozone: A multifaceted molecule with unexpected therapeutic activity[J].Curr Med Chem, 2016, 23(4): 304-314.
Braidy N, Izadi M, Sureda A, et al. Therapeutic relevance of ozone therapy in degenerative diseases: Focus on diabetes and spinal pain[J].J Cell Physiol, 2018, 233(4): 2705-2714.
0
浏览量
117
下载量
0
CSCD
关联资源
相关文章
相关作者
相关机构